Faculty Publications

July 1, 2012-June 30, 2013

Dr. Leon Avery

Artyukhin AB, Yim JJ, Srinivasan J, Izrayelit Y, Bose N, von Reuss SH, Jo Y, Jordan JM, Baugh LR, Cheong M, Sternberg PW, Avery L, Schroeder FC. Succinylated octopamine ascarosides and a new pathway of biogenic amine metabolism in C elegans.  J Biol Chem. 2013 Jun 28;288(26):18778-83.

Cheong MC, Lee H-J, Na K, Joo H-J, Avery L, You YJ, Paik Y-K .  NSBP-1 Mediates the Effects of Cholesterol on Insulin/IGF-1 Signaling in Caenorhabditis elegans.  Cell Mol Life Sci. 2013 May;70(9):1623-36.

Gallagher, T, Bjorness, T, Greene, R, You, Y-J, Avery L. The geometry of locomotive behavioral states in C. elegans.  PLoS One. 2013;8(3):e59865. Epub 2013 Mar 28.

Song B, Faumont S, Lockery S, Avery L. Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans.  Elife. 2013;2:e00329. Epub 2013 Feb 5.

You, Y, Avery, L .  Appetite control: worm’s-eye view. Animal Cells Syst (Seoul). 2012 Oct;16(5):351-356.

Dr. Richard Costanzo

Teves ME, Zhang Z, Costanzo RM, Henderson SC, Corwin FD, Zweit J, Sundaresan G, Subler M, Salloum FN, Rubin BK and Strauss JF, 3rd. Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival. Am J Respir Cell Mol Biol. 2013 Jun;48(6):765-72.

Costanzo RM, Reiter RJ and Yelverton JC.  Smell and Taste. In: Brain Injury Medicine: Principles and Practice, edited by Zasler ND, Katz DI and Zafonte RD.  New York: Demos, 2012, p. 794-808.

Dr. Meng Cui

Dewis ML, Phan TH, Ren Z, Meng X, Cui M, Mummalaneni S, Rhyu MR, DeSimone JA, Lyall V. N-Geranyl-cyclopropyl-carboximide modulates salty and umami taste in humans and animal models. J Neurophysiol. 2013 Feb;109(4):1078-90.

Wang Y, Zhang M, Xu Y, Jiang M, Zankov DP, Cui M, Tseng GN. Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2. J Gen Physiol. 2012 Dec;140(6):653-69.

Liu B,  Ha M, Meng XY, Khaleduzzaman M,  Zhang Z,  Li X, Cui M. Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins. Biochem Biophys Res Commun. 2012 Oct 19;427(2):431-7.

Rodriguez-Menchaca AA, Adney SK, Tang QY, Meng XY, Rosenhouse-Dantsker A, Cui M, Logothetis DE. PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):E2399-408.

Dr. Louis De Felice

Bonano JS, Glennon RA, De Felice LJ, Banks ML, Negus SS. Abuse-related and abuse-limiting effects of methcathinone and the synthetic "bath salts" cathinone analogs methylenedioxypyrovalerone (MDPV), methylone and mephedrone on intracranial self-stimulation in rats. Psychopharmacology (Berl). 2013 Aug 15. [Epub ahead of print]

Cameron KN, Kolanos R, Solis E, De Felice LJ, Glennon R. Bath salts components mephedrone and methylenedioxypyrovalerone (MDPV) act synergistically at the human dopamine transporter. Br J Pharmacol. 2013 Apr;168(7):1750-7.

Cameron KN, Kolanos R, Verkariya R, De Felice L, Glennon RA. Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of “bath salts,” produce opposite effects at the human dopamine transporter.  Psychopharmacology (Berl). 2013 Jun;227(3):493-9.

Dr. Jose M. Eltit


Eltit JM, Ding X, Pessah IN, Allen PD, Lopez JR. Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia. FASEB J. 2013 Mar;27(3):991-1000.

Dr. Carlos Escalante

Zarate-Perez F, Mansilla-Soto J, Bardelli M, Burgner JW 2nd, Villamil-Jarauta M, Kekilli D, Samso M, Linden RM, Escalante CR.  Oligomeric properties of adeno-associated virus Rep68 reflect its multifunctionality. J Virol. 2013 Jan;87(2):1232-41.

Glasmacher E, Agrawal S, Chang AB, Murphy TL, Zeng W, Lugt BV, Khan AA, Ciofani M, Spooner C, Rutz S, Hackney J, Nurieva R, Escalante CR, Ouyang W, Littman DR, Murphy KM, Singh H.  A genomic regulatory element that directs assembly and function of immune-specific AP-1 IRF complexes. Science. 2012 Nov 16;338(6109):975-80.

Dr. John Grider Bhattacharya S, Mahavadi S, Al-shboul O, Rajagopal S, Grider JR, and Murthy KS. Differential regulation of muscarinic m2 and m3 receptor signaling in gastrointestinal smooth muscle by caveolin-1. Am J Physiol Cell Physiol. 2013 Aug;305(3):C334-47.

Ren Z. Rhyu MR., Phan TH, Mummalaneni S., Murthy KS., Grider JR, Desimone JA, and Lyall V.  TRPm5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response. Am J Physiol Gastrointest Liver Physiol. 2013 Jul;305(1):G106-17.

Siwai W,  Mahavadi  S, Al-Shboul O, Grider JR, Murthy KS.  Distinctive G protein-dependent signaling by protease-activated receptor 2 (PAR2) in smooth muscle: feedback inhibition of RhoA by cAMP-independent PKA.  PLoS One. 2013 Jun 18;8(6):e66743.

Ahmed R, Mahavadi S, Al-Shboul O, Bhattacharya S, Grider JR, Murthy KS. Characterization of signaling pathways coupled to melatonin receptors in gastrointestinal smooth muscle.  Regul Pept. 2013 Jun 10;184:96-103.

Hawkins EG, Dewey WL, Anitha M, Srinivasan S, Grider JR, Akbarali HI. Electrophysiological Characteristics of Enteric Neurons Isolated from the Immortomouse. Dig Dis Sci. 2013 Jun;58(6):1516-27.

Mahavadi S, Bhattacharya S, Kim J, Fayed S, Al-Shboul O, Grider JR, Murthy KS. Caveolae-dependent internalization and homologous desensitization of VIP/PACAP receptor, VPAC2, in gastrointestinal smooth muscle. Peptides. 2013 May;43:137-45.

Rajagopal S, Kumar DP, Mahavadi S, Bhattacharya S, Zhou R, Corvera CU, Bunnett NW, Grider JR, Murthy KS.  Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of
RhoA/Rho kinase pathway. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G527-35.

Alemi F, Poole DP, Chiu J, Schoonjans K, Cattaruzza F, Grider JR, Bunnett NW, Corvera CU. The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology. 2013 Jan;144(1):145-54.

Yu SJ, Grider JR, Gulick MA, Xia CM, Shen S, Qiao LY.  Up-regulation of brain-derived neurotrophic factor is regulated by extracellular signal-regulated protein kinase 5 and by nerve growth factor retrograde signaling in colonic afferent neurons in colitis. Exp Neurol. 2012 Dec;238(2):209-17.

Kumar DP, Rajagopal S, Mahavadi S, Mirshahi F, Grider JR, Murthy KS, Sanyal AJ. Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells. Biochem Biophys Res Commun. 2012 Oct 26;427(3):600-5.

Smith TH, Grider JR, Dewey WL, Akbarali HI. Morphine decreases enteric neuron excitability via inhibition of sodium channels. PLoS One. 2012;7(9):e45251.

Dr. John Hackett


Elenewski JE, Hackett JC.  Cytochrome P450 Compound I in the plane wave pseudopotential framework: GGA electronic and geometric structure of thiolate-ligated iron(IV)-oxoporphyrin.  J Comput Chem. 2013 Jul 15l34(19):1647060.

Elenewski JE, Hackett JC.  Solvatochromism and the solvation structure of benzophenone.  J Chem Phys. 2013 Jun 14;138(22):224308

Dr. S. Murthy Karnam

Bhattacharya S, Mahavadi S, Al-Shboul O, Rajagopal S, Grider JR, and Murthy KS. Differential regulation of muscarinic M2 and M3 receptor signaling in gastrointestinal smooth muscle by caveolin-1. Am J Physiol Cell Physiol. 2013 Aug;305(3):C334-47.

Ren Z. Rhyu MR., Phan TH, Mummalaneni S., Murthy KS., Grider JR, Desimone JA, and Lyall V.  TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response. Am J Physiol Gastrointest Liver Physiol. 2013 Jul;305(1):G106-17.

Alkahtani R, Mahavadi S, Al-Shboul, O, Alsharari, S, Grider, JR., and Murthy KS. Changes in the expression of smooth muscle contractile proteins in TNBS- and DSS-Induced Colitis in mice. Inflammation. 2013 Jun 22. [Epub ahead of print]

Sriwai W,  Mahavadi  S, Al-Shboul O, Grider JR, Murthy KS.  Distinctive G protein-dependent signaling by protease-activated receptor 2 (PAR2) in smooth muscle: feedback inhibition of RhoA by cAMP-independent PKA.  PLoS One. 2013 Jun 18;8(6):e66743.

Al-Shboul O, Mahavadi S, Sriwai W, Grider JR, and Murthy KS. Differential expression of multidrug-resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2013 Jun 13. [Epub ahead of print]

Ahmed R, Mahavadi S, Al-Shboul O, Bhattacharya S, Grider JR, Murthy KS. Characterization of signaling pathways coupled to melatonin receptors in
gastrointestinal smooth muscle.  Regul Pept. 2013 Jun 10;184:96-103.

Mahavadi S, Nalli A, Al-Shboul O, and Murthy KS. Inhibition of MLC20 phosphorylation downstream of Ca2+ and RhoA: a novel mechanism involving phosphorylation of myosin phosphatase interacting protein (M-RIP) by PKG and stimulation of MLC phosphatase activity.  Cell Biochem Biophys. 2013 May 31. [Epub ahead of print]

Mahavadi S, Bhattacharya S, Kim J, Fayed S, Al-Shboul O, Grider JR, Murthy KS. Caveolae-dependent internalization and homologous desensitization of VIP/PACAP receptor, VPAC2, in gastrointestinal smooth muscle. Peptides. 2013 May;43:137-45.

Rajagopal S, Kumar DP, Mahavadi S, Bhattacharya S, Zhou R, Corvera CU, Bunnett NW, Grider JR, Murthy KS.  Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G527-35.

Kumar DP, Rajagopal S, Mahavadi S, Mirshahi F, Grider JR, Murthy KS, Sanyal AJ. Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic ? cells. Biochem Biophys Res Commun. 2012 Oct 26;427(3):600-5.

Dr. Qinglian Liu

Qi R, Sarbeng EB, Liu Q, Le KQ, Xu X, Xu H, Yang J, Wong JL, Vorvis C, Hendrickson WA, Zhou L, Liu Q. Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP. Nat Struct Mol Biol. 2013 Jul;20(7):900-7.

Liu Q, Liu Q and Hendrickson WA.  Robust structural analysis of native biological macromolecules from multi-crystal anomalous diffraction data. Acta Crystallogr D Biol Crystallogr. 2013 Jul;69(Pt 7):1314-32

Xu X, Marni F, Wu S, Su Z, Musayev F, Shrestha S, Xie C, Gao W, Liu Q, Zhou L.  Local and global interpretations of a disease causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated (HCN) channel. Structure. 2012 Dec 5;20(12):2116-23.

Marni F, Wu S, Shah GM, Xu XP, Hackett AR, Xie C, Shrestha S, Liu L, Liu Q, Zhou L. Normal-mode-analysis-guided investigation of crucial intersubunit contacts in the cAMP-dependent gating in HCN channels. Biophys J. 2012 Jul 3;103(1):19-28.

Dr. Diomedes Logothetis

Mahajan R, Ha J, Zhang M, Kawano T, Kozasa, T, Logothetis DE. A computational model predicts that G?? acts at a cleft between channel subunits to activate GIRK1 channels. Sci Signal. 2013 Aug 13;6(288):ra69.

Rosenhouse-Dantsker A, Noskov S, Logothetis DE, Levitan I. Cholesterol sensitivity of KIR2.1 depends on Functional inter-links between the N and C termini. Channels (Austin). 2013 Jun 27;7(4).

Zhang Z, Tang Q-Y, Alaimo JT, Davies AG, Bettinger JC, and Logothetis DE. SLO-2 isoforms with unique Ca2+- and voltage-dependence characteristics confer sensitivity to hypoxia in C. elegans.  Channels (Austin). 2013 May-Jun;7(3):194-205.

Zhou L, Logothetis DE. The where and how of PIP regulation of cone photoreceptor CNG channels. J Gen Physiol. 2013 Apr;141(4):403-7.
 
Rodríguez-Menchaca AA, Adney SK, Zhou L, Logothetis DE. Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2). Front Pharmacol. 2012;3:170.

An HL, Lü SQ, Li JW, Meng XY, Zhan Y, Cui M, Long M, Zhang HL, Logothetis DE. The cytosolic GH loop regulates the phosphatidylinositol 4,5-bisphospate-induced gating kinetics of Kir2 channels.  J Biol Chem. 2012 Dec 7;287(50):42278-87.

Rosenhouse-Dantsker A, Noskov S, Han H, Adney SK, Tang QY, Rodríguez-Menchaca AA, Kowalsky GB, Petrou VI, Osborn CV, Logothetis DE, Levitan I.  Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)). J Biol Chem. 2012 Nov 23;287(48):40266-78.

Rodriguez-Menchaca AA, Adney SK, Tang QY, Meng XY, Rosenhouse-Dantsker A, Cui M, Logothetis DE. PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):E2399-408.

Dr. Vijay Lyall

Ren Z. Rhyu MR., Phan TH, Mummalaneni S., Murthy KS., Grider JR, Desimone JA, and Lyall V.   TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response. Am J Physiol Gastrointest Liver Physiol. 2013 Jul;305(1):G106-17.

Zha BS, Wan X, Zhang X, Zha W, Zhou J, Wabitsch M, Wang G, Lyall V, Hylemon PB, Zhou H. HIV protease inhibitors disrupt lipid metabolism by activating endoplasmic reticulum stress and inhibiting autophagy activity in adipocytes. PLoS One. 2013;8(3):e59514.

Dewis ML, Phan TH, Ren Z, Meng X, Cui M, Mummalaneni S, Rhyu MR, DeSimone JA, Lyall V. N-Geranyl-cyclopropyl-carboximide modulates salty and umami taste in humans and animal models. J Neurophysiol. 2013 Feb;109(4):1078-90.

Desimone JA, Phan TH Ren Z, Mummalaneni S, Lyall V. Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to bitter, sweet, and umami taste stimuli. J Neurophysiol. 2012 Dec;108(12):3221-32.

DeSimone JA, Ren Z, Phan TH T, Heck GL, Mummalaneni S  and Lyall V. Changes in Taste Receptor Cell [Ca2+]i Modulate Chorda Tympani Responses to Salty and Sour Taste Stimuli. J Neurophysiol. 2012 Dec;108(12):3206-20.

Dr. Roland Pittman

Golub AS, Pittman RN. Bang-bang model for regulation of local blood flow. Microcirculation. 2013 Aug;20(6):455-83.

Song BK, Nugent WH, Moon-Massat PF, Auker CR, McCarron R, and Pittman RN. Effects of top-loading a zero-link bovine hemoglobin, OxyVita, on systemic and microcirculatory variables. Mil Med. 2013 May;178(5):570-7.

Pittman, RN.  Oxygen transport in the microcirculation and its regulation.  Microcirculation. 2013 Feb;20(2):117-37.

Dr. Liya Qiao

Yu SJ, Grider JR, Gulick MA, Xia CM, Shen S, Qiao LY.  Up-regulation of brain-derived neurotrophic factor is regulated by extracellular signal-regulated protein kinase 5 and by nerve growth factor retrograde signaling in colonic afferent neurons in colitis. Exp Neurol. 2012 Dec;238(2):209-17.

Yu SJ, Xia CM, Kay JC, Qiao LY. Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons. Mol Pain. 2012 Jun 28;8:48.

Dr. Montserrat Samso

Zarate-Perez F, Mansilla-Soto J, Bardelli M, Burgner JW 2nd, Villamil-Jarauta M, Kekilli D, Samso M, Linden RM, Escalante CR.  Oligomeric properties of adeno-associated virus Rep68 reflect its multifunctionality. J Virol. 2013 Jan;87(2):1232-41.

Szpyt J, Lorenzon N, Perez CF, Norris E, Allen PD, Beam KG, Samsó M. Three-dimensional localization of the ? and ? subunits and of the II-III loop in the skeletal muscle L-type Ca2+ channel. J Biol Chem. 2012 Dec 21;287(52):43853-61.

Ramachandran S, Chakraborty A, Xu L, Mei Y, Samso M, Dokholyan NV, Meissner G.  Structural determinants of skeletal muscle ryanodine receptor gating. J Biol Chem. 2013 Mar 1;288(9):6154-65.

Dr. Gea-Ny Tseng

Wang Y, Zhang M, Xu Y, Jiang M, Zankov DP, Cui M, Tseng GN. Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2. J Gen Physiol. 2012 Dec;140(6):653-69.

Tseng GN. Short-term memory in the heart: a road map for channel trafficking required. Heart Rhythm. 2012 Nov;9(11):1873-4.

Dr. Carlos Villalba-Galea

Ruscic KJ, Miceli F, Villalba-Galea CA, Dai H, Mishina Y, Bezanilla F, Goldstein SA. IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits.  Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):E559-66.

Halaszovich CR, Leitner MG, Mavrantoni A, Le A, Frezza L, Feuer A, Schreiber DN, Villalba-Galea CA, Oliver D. A human phospholipid phosphatase activated by a transmembrane control module. J Lipid Res. 2012 Nov;53(11):2266-74.

Labro AJ, Lacroix JJ, Villalba-Galea CA, Snyders DJ, Bezanilla F. Molecular mechanism for depolarization-induced modulation of Kv channel closure. J Gen Physiol. 2012 Nov;140(5):481-93.

Villalba-Galea CA. Voltage-Controlled Enzymes: The New JanusBifrons. Front Pharmacol. 2012;3:161. Epub 2012 Sep 13.

Dr. Lei Zhou

Qi R, Sarbeng EB, Liu Q, Le KQ, Xu X, Xu H, Yang J, Wong JL, Vorvis C, Hendrickson WA, Zhou L, Liu Q. Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP. Nat Struct Mol Biol. 2013 Jul;20(7):900-7.

Zhou L, Logothetis DE. The where and how of PIP regulation of cone photoreceptor CNG channels. J Gen Physiol. 2013 Apr;141(4):403-7.

Xu X, Marni F, Wu S, Su Z, Musayev F, Shrestha S, Xie C, Gao W, Liu Q, Zhou L.  Local and global interpretations of a disease causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated (HCN) channel. Structure. 2012 Dec 5;20(12):2116-23.

Rodríguez-Menchaca AA, Adney SK, Zhou L, Logothetis DE. Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2). Front Pharmacol. 2012 Sep 25;3:170.

Marni F, Wu S, Shah GM, Xu XP, Hackett AR, Xie C, Shrestha S, Liu L, Liu Q, Zhou L. Normal-mode-analysis-guided investigation of crucial intersubunit contacts in the cAMP-dependent gating in HCN channels. Biophys J. 2012 Jul 3;103(1):19-28.